IMMUNOBIOLOGY CCL21 mediates CD4 T-cell costimulation via a DOCK2/Rac-dependent pathway
نویسندگان
چکیده
1Theodor Kocher Institute, University of Bern, Bern, Switzerland; 2Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique (UMR 8104), Paris, France; 3Inserm (U567), Paris, France; 4Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan; 5Japan Science and Technology, CREST, Tokyo, Japan; 6Laboratory of Lymphocyte Signaling and Development, Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom; 7Center for Cell Signaling, Institute of Cancer, Queen Mary University of London, London, United Kingdom; and 8Department of Basic Sciences, Fox Chase Cancer Center, Philadelphia, PA
منابع مشابه
CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway.
CD4(+) T cells use the chemokine receptor CCR7 to home to and migrate within lymphoid tissue, where T-cell activation takes place. Using primary T-cell receptor (TCR)-transgenic (tg) CD4(+) T cells, we explored the effect of CCR7 ligands, in particular CCL21, on T-cell activation. We found that the presence of CCL21 during early time points strongly increased in vitro T-cell proliferation after...
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تاریخ انتشار 2009